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Brezofil Syrup 100ml
Brezofil contains Doxophylline, a bronchodilator with a distinct molecular structure featuring a dioxolane group at position 7. Unlike Theophylline, it selectively inhibits phosphodiesterase 4 (PDE4), leading to bronchial smooth muscle relaxation.
🔬 Key benefits of Doxophylline:
✔ Lower affinity for adenosine A1 and A2 receptors, ensuring a better safety profile.
✔ Inhibits platelet-activating factor (PAF) and reduces leukotriene production, helping in airway inflammation control.
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✅ Description:
Brezofil is prescribed for the treatment of the following respiratory conditions:
✅ Bronchial asthma
✅ Bronchospasm
✅ Chronic obstructive pulmonary disease (COPD)
✅ Pulmonary diseases with a spastic bronchial component
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Brezofil Syrup
For Elderly Patients:
💊 200 mg tablet – twice or three times daily.
For Adults:
💊 400 mg tablet – twice or three times daily (or as prescribed by the physician).
For Children:
👦 Above 12 years: 10 ml syrup or 200 mg tablet – twice or three times daily.
👧 6-12 years: 6-9 mg/kg body weight, twice daily. (Example: If a child weighs 10 kg, the dose is 3 ml (60 mg) twice daily.)
🔹 If the daily requirement of Doxophylline is 400 mg, a sustained-release (SR) tablet should be taken once daily.
✔️ Possible Side Effects of Brezofil
Patients taking Brezofil may experience:
⚠ Common side effects:
- Nausea, vomiting, and stomach pain.
- Headache, irritability, and difficulty sleeping (insomnia).
- Rapid heartbeat (tachycardia) and irregular heartbeats (extrasystoles).
- Breathing difficulties (tachypnea).
⚠ Rare side effects:
- High blood sugar levels (hyperglycemia).
- Protein in urine (albuminuria).
⚠ Overdose Warning:
- May cause severe heart rhythm disturbances and tonic-clonic seizures.
- If overdose symptoms appear, discontinue use immediately and seek medical attention.
- Treatment may be resumed at lower doses once symptoms subside.
✔️ Drug Interactions – What to Avoid While Taking Brezofil?
🚫 Do not take Brezofil with other xanthine-based medications.
🚫 Limit the intake of caffeine-containing foods and beverages.
🚫 Caution is advised when used with:
- Ephedrine or other sympathomimetic drugs (may increase side effects).
- Antibiotics (Erythromycin, Lincomycin, Clindamycin, TAO) (may increase drug levels).
- Allopurinol, Cimetidine, Influenza vaccine, and Propranolol (may slow drug clearance, raising plasma levels).
- Phenytoin and anticonvulsants, as well as cigarette smoking, (may speed up drug clearance, reducing effectiveness).
✔️ Contraindications – Who Should Not Take Brezofil?
🚫 Do not use Brezofil if you have:
❌ Allergic reactions to Doxophylline or other xanthine derivatives.
❌ Recent heart attack (acute myocardial infarction).
❌ Low blood pressure (hypotension).
❌ Pregnancy and breastfeeding (contraindicated during lactation)
✔️ Overdose Management
🚨 Symptoms of overdose:
- Severe heart arrhythmias.
- Tonic-clonic seizures (convulsions).
- Signs of toxicity like extreme nausea, tremors, or agitation.
⚕ Treatment:
- There is no specific antidote.
- Symptomatic treatment should be provided to manage cardiovascular collapse.
- Discontinue the drug and seek immediate medical attention.
✔️ Use During Pregnancy & Lactation
Pregnant Women:
- Animal studies indicate that Doxophylline does not interfere with fetal development.
- However, due to limited clinical evidence, it should only be used if the benefits outweigh the risks.
Breastfeeding Mothers:
- Brezofil is contraindicated during lactation due to insufficient data on its presence in breast milk.
✔️ Precautions & Warnings
✅ Dosage Adjustments May Be Needed In:
- Elderly patients.
- Patients with chronic liver disease or severe infections.
- People with chronic obstructive pulmonary disease (COPD).
- Patients with heart conditions (hypertension, heart failure, or chronic corpulmonale).
- People with hyperthyroidism or severe low oxygen levels (hypoxemia).
📌 In patients with congestive heart failure, drug clearance is slower, leading to prolonged high blood levels even after discontinuation.
✅ No Risk of Addiction:
✔️ Storage Instructions
📌 Store in a dry place, away from light and heat.
📌 Keep out of reach of children.
📌 Use only as prescribed by a specialist physician.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
